Reduction In Flow Research Articles

Celastrol ameliorates hypoxic-ischemic brain injury in neonatal rats by reducing oxidative stress and inflammation.

Hypoxic-ischemic encephalopathy (HIE) is caused by perinatal hypoxia and subsequent reductions in cerebral blood flow and is one of the leading causes of severe disability or death in newborns. Despite its prevalence, we currently lack an effective drug therapy to combat HIE. Celastrol (Cel) is a pentacyclic triterpene extracted from Tripterygium Wilfordi that can protect against oxidative stress, inflammation, and cancer. However, whether Cel can alleviate neonatal hypoxic-ischemic (HI) brain damage remains unclear. Here, we established both in vitro and in vivo models of HI brain damage using CoCl2-treated PC12 cells and neonatal rats, respectively, and explored the neuroprotective effects of Cel in these models. Analyses revealed that Cel administration reduced brain infarction size, microglia activation, levels of inflammation factors, and levels of oxidative stress markers by upregulating levels of p-AMPKα, Nrf2, HO-1, and by downregulating levels of TXNIP and NLRP3. Conversely, these beneficial effects of Cel on HI brain damage were largely inhibited by AMPKα inhibitor Compound C and its siRNA. We present compelling evidence that Cel decreases inflammation and oxidative stress through the AMPKα/Nrf2/TXNIP signaling pathway, thereby alleviating neonatal HI brain injury. Cel therefore represents a promising therapeutic agent for treating HIE. We firstly report that celastrol can ameliorate neonatal hypoxic-ischemic brain injury both in in vivo and in vitro, which represents a promising therapeutic agent for treating related brain injuries. Celastrol activates the AMPKα/Nrf2/TXNIP signaling pathway to relieve oxidative stress and inflammation and thereby alleviates neonatal hypoxic-ischemic brain injury.

Europe and Arab States’ Migration-related Instruments with Africa: Dilemma of Soft Power and Conflictual Interests

The national and regional interests of the European Union, oil-rich Gulf Cooperation Council and Africa are conflictual in addressing international labour migration. This underscores the structure and ineffectiveness of bilateral migration instruments. The European Union canvasses for migrants’ returns, readmission and outsourcing of national border controls; Arab states show reluctance to stop the predominant employer–sponsorship system that curtails labour migrants’ human rights, while African states detest migrants’ return and readmission, and prefer liberalisation of legal migration and flow of remittances. This article is anchored on the hegemonic stability and regime frame of interventionist liberalism theoretical perspectives to highlight Europe’s soft power in migration partnerships or agreements deployed via financial aid and development projects as a way to drive the migration-development-security nexus with African countries. Essentially, African states’ asymmetric economic relationship with Europe has accentuated the carrot-and-stick approach, while Arab states’ slow pace in allowing the mobility of African labour migrants has led to a reduction in remittance flows. It is recommended that the dialogues between the regional blocs and countries leading to labour migration agreements must find a common ground of mutual interests for effective partnerships to emerge.

FIRST ITALIAN CASE OF TRANSCATHETER TREATMENT OF AORTIC REGURGITATION IN L–VAD PATIENT WITH A DEDICATED DEVICE

Abstract In patients with L–VADs, aortic valve regurgitation is a relatively frequent complication often associated with high mortality. Surgical approaches are extremely complex and often lead to poor outcomes. TAVI can be a feasible solution but it is usually extremely challenging due to the absence of calcification and stenosis. We report the case of a 56–year–old man who underwent LVAD implantation 4years ago as destination therapy for dilated myocardiopathy and chronic multiple myeloma. During the last year, he progressively developed severe pure aortic regurgitation. Last month, he was admitted to our center for heart failure symptoms and recurrent ventricular arrhythmias (VT/VF). The patient was considered at high risk for surgery and evaluated for a transcatheter approach. Due to the absence of calcification and a relatively large annulus, we decided to use the JenaValve Trilogy prosthesis, the only THV CE approved for aortic regurgitation treatment. Unlike other types of THV (self– or balloon expandable), this is specifically designed for AR and does not require significant oversizing to allow correct anchoring. Another advantage in this setting is the possibility of avoiding the reduction of the LVAD flow due to the reduced risk of embolization and the possibility of proceeding to direct implantation without ventricular rapid pacing thanks to the direct anchoring method onto the native aortic leaflets. In this patient, a JenaValve size L bioprosthesis was implanted transfemorally under general anesthesia with an excellent result. The post–operative echocardiography showed a perfectly implanted prosthesis with no intraprosthesis regurgitation and only a mild anterior paravalvular leak with a subsequent improvement of all hemodynamic parameters. In our opinion, when feasible, the JenaValve implant can be a safe and effective therapeutic option in patients with active LVAD devices at high operative risk.

Anesthesia-induced Lymphatic Dysfunction.

General anesthetics adversely alters the distribution of infused fluid between the plasma compartment and the extravascular space. This maldistribution occurs largely from the effects of anesthetic agents on lymphatic pumping, which can be demonstrated by macroscopic fluid kinetics studies in awake versus anesthetized patients. The magnitude of this effect can be appreciated as follows: a 30% reduction in lymph flow may result in a fivefold increase of fluid-induced volume expansion of the interstitial space relative to plasma volume. Anesthesia-induced lymphatic dysfunction is a key factor why anesthetized patients require greater than expected fluid administration than can be accounted for by blood loss, urine output, and insensible losses. Anesthesia also blunts the transvascular refill response to bleeding, an important compensatory mechanism during hemorrhagic hypovolemia, in part through lymphatic inhibition. Last, this study addresses how catecholamines and hypertonic and hyperoncotic fluids may mobilize interstitial fluid to mitigate anesthesia-induced lymphatic dysfunction.

Rheology modification of flowable mortar with CO2

The rheological properties of mortar samples with different additions of CO2 during mixing were determined. Flowable cement-based mortars at three different w/c (0.55, 0.45 and 0.35) were produced and the effects of CO2 gas were examined on the fresh properties of slump flow, yield stress and plastic viscosity. According to the experimental results, the mortar yield stress and plastic viscosity increased faster over time than in a reference system with the increasing addition of CO2 and greater effects were seen at the lowest w/c of 0.35 than at the others. The impact of the CO2 on the yield stress was more pronounced than on the viscosity. In the w/c 0.35 system the properties showed no effect at dosages of 0.06% and 0.13% CO2 by weight of cement. Increasing dosages to 0.19 and 0.25% resulted in an increasing reduction in slump flow, immediate increases in yield stress of 62 and 298%, increases in structural buildup by a factor of 5 and 10, respectively, and increased the initial plastic viscosity by 33 and 148%, respectively. The effects are attributable to the growth of reaction products decreasing the interparticle spacing and increasing the surface area as associated with the CaCO3 and gel phase. CO2 was demonstrated to be a potential yield stress control agent; an appropriate dose can increase rheological properties as measured immediately after and increase their rate of change with time. This aligns with specialized applications that hinge upon changing rheology such as form pressure control or 3D concrete printing.

Does online high-volume hemodiafiltration offer greater efficiency and sustainability compared to high-flux hemodialysis? A detailed simulation analysis anchored in real-world data

Abstract Recent findings, including the CONVINCE study report, suggests the superiority of high-volume hemodiafiltration over high-flux hemodialysis in improving patients’ outcomes. Despite positive patient outcomes, concerns have arisen about the potential negative environmental impact of high-volume hemodiafiltration, as it may lead to increased water and dialysis fluid consumption and higher waste production. In this manuscript, we address the environmental impact of high-volume HDF, focusing on three key factors: water treatment consumption, dialysis fluid consumption, and solute efficiency markers of HD and HDF. By optimizing HDF prescription through adjustments in operational capabilities, such as reducing the QD/QB ratio to 1,2 rather than 1,5 and incorporating automated ultrafiltration and substitution control, it has been demonstrated that HDF delivers a higher dialysis dose for small and middle-molecule uremic compounds with the same dialysis fluid consumption and at equal dialysis doses dialysis fluid consumption is reduced. This finding is supported by real-world data from 26 031 patients who underwent high-volume postdilution hemodiafiltration at a reduced dialysis flow (550 ml/min) and achieved an effective OCMKt/V of 1.70. In addition, simulation modeling calculations, using blood extraction coefficient, dialysate saturation coefficient, and solute clearances with urea (small MW) and ß2M (middle MW), consistently show postdilution HDF's superiority to HD. This holds true even with a significant reduction in dialysis flow down to 440 ml/min reflecting QD/QB ratio of 1,2. Postdilution HDF generates high ultrafiltrate flow (up to 35% of blood flow), delivering saturated ultrafiltrate to the lower solute concentration containing effluent dialysate, thus enhancing solute clearance which opens the way to reduce the dialysis flow. In conclusion, our analysis, combining simulation and real-world data, suggests that postdilution HDF could be a more environmentally friendly treatment option compared to conventional hemodialysis. Additionally, automated user-friendly functions that minimize dialysis fluid use, can further strengthen this environmental benefit while enhancing efficiency.

Assessment of hydrological baseline condition and its alteration in Athabasca River Basin, Canada

Study regionAthabasca River Basin (ARB), Canada. Study focusThis study aimed to characterize the flow regime of the ARB, a basin with diverse hydroclimatic and geological characteristics. Forty-two different flow indicators from the Indicators of Hydrological Alteration (IHA) and Cold regions Hydrological Indicators of Change (CHIC) were employed. The natural range of these indicators was established for the baseline period (1961–1990), and subsequent alterations during the recent period (1991–2020) were systematically examined. Principal Component Analysis (PCA) was applied to identify pivotal indicators shaping the basin's flow regime. In addition, trends of key indicators were examined at eight distinct locations within the basin. New hydrological insights for the study regionThe findings indicate spatiotemporal variation between the basin's upper and lower parts. The upstream region exhibited an earlier peak flow (9 days), an earlier ice break-up (17 days), and a shorter ice cover duration (22 days) compared to the downstream region. Increased winter and spring flow have led to an augmentation of annual flow by 3.8 % in the upper region. In contrast, downstream flow experienced a decline throughout the year (11.38 %), which was found to be statistically significant at a rate of 3.24 m3/s/year. Alteration analysis revealed a shift toward the 'low category' (below their defined baseline range) for most indicators in the recent period, underscoring a transition towards a diminishing flow regime, with an overall alteration ranging at low to moderate levels (19–38 %). Late summer flow reduction (8–25 %) can have critical implications, given the rising water demand in the basin. The study identified eleven key indicators encapsulating the basin's flow regime variability range. It was found that ice cover, its break-up, and spring freshet significantly influence the flow regime of the basin. The findings from this study will assist decision-makers in making more informed decisions for the holistic management of water resources in the basin.

Multi-Scenario analysis of rooftop greening regulation on runoff effects based on adaptive Evaluation: A case study of Macau, China

The reduction in internal ecological spaces within urban environments and the expansion of impervious surfaces have been identified as factors significantly increasing the susceptibility of cities to flood disasters. Rooftop greening, an essential component of urban stormwater management strategies, offers a versatile solution for augmenting permeable surfaces and delivering ecological services while seamlessly integrating with existing urban infrastructure. This approach has been proven effective in enhancing urban resilience against rainfall-induced flooding events. Hence, the precise identification of suitable building rooftops for green infrastructure within urbanized regions, combined with the simulation of runoff regulation effects brought about by these rooftop greening interventions, holds substantial practical significance. This study innovatively constructs a technical method for measuring the runoff control performance of urban-scale green roofs from identification, evaluation to simulation. Taking the Macao Special Administrative Region as an example, a green roof suitability evaluation index system that is consistent with urban characteristics has been constructed, integrating machine learning, comprehensive evaluation, SWMM simulation methods to evaluate the suitability of roof greening in urban areas and simulate the impact of multi-senarios green roof construction types on runoff regulation. Finally, a comprehensive strategy for rooftop greening construction in Macau is proposed, with the aim of amplifying the runoff regulation capabilities of such initiatives. The main findings of the research include the following: (1) The research area exhibits a notably high aggregate potential for rooftop greening, with suitable rooftop areas comprising approximately 34% of the total rooftop expanse. Notably, construction vintage and roof elevation are identified as the most substantive constraints on rooftop greening. (2) Discernible differences in rooftop greening construction scale exert a significant influence on runoff regulation capacity, with the magnitude of greening positively correlated with its runoff regulation efficacy. Distinct greening typologies elicit varying impacts on runoff regulation, with semi-intensive rooftop greening surpassing extensive approaches in runoff regulation performance. Disparate distribution patterns of rooftop greening engender dissimilar runoff regulation effects, with rooftop greening layouts situated distant from drainage outlets facilitating runoff mitigation, while those in close proximity to drainage outlets enhance peak flow reduction effects.

Drift drives the evolution of chromosome number II: The impact of range size on genome evolution in Carnivora.

Chromosome number is a fundamental genomic trait that is often the first recorded characteristic of a genome. Across large clades, a common pattern emerges: many or even most lineages exhibit relative stasis, while a handful of lineages or species exhibit striking variation. Despite recent developments in comparative methods, most of this heterogeneity is still poorly understood. It is essential to understand why some lineages have rapid rates of chromosome number evolution, as it can impact a variety of other traits. Previous research suggests that biased female meiotic drive may shape rates of karyotype evolution in some mammals. However, Carnivora exhibits variation that this female meiotic drive model cannot explain. We hypothesize that variation in effective population size may underlie rate variation in Carnivora. To test this hypothesis, we estimated rates of fusions and fissions while accounting for range size, which we use as a proxy for effective population size. We reason fusions and fissions are deleterious or underdominant and that only in lineages with small range sizes will these changes be able to fix due to genetic drift. In this study, we find that the rates of fusions and fissions are elevated in taxa with small range sizes relative to those with large range sizes. Based on these findings, we conclude that 1) naturally occurring structural mutations that change chromosome number are underdominant or mildly deleterious, and 2) when population sizes are small, structural rearrangements may play an important role in speciation and reduction in gene flow among populations.

A synthetic indicator for structuring resilient public transport operation

ABSTRACT This study introduces a synthetic resilience indicator as a unified analytical tool to evaluate public transport resilience, assessing performance changes in bus networks against random disruptions. This methodology measures the cumulative impact of disruptions, considering the network’s capacity for maintaining planned functionality (robustness and reliability) and recoverability (i.e., route diversity), factoring in network topology, passenger flow, and resource diversity. This paper analyzes the impact of disruptions at network and station levels by applying an index to six benchmark networks. Our findings reveal: (1) networks with high station connectivity maintain robustness and flow; (2) a clear link between flow reduction and alternate routes highlights route diversity’s value; (3) interplay between topological and flow-related network attributes underlines the need for an aggregated analytical approach. The proposed index can be used as an optimization goal during route network design; informing operators regarding the impact of design choices on future network properties.

The role of coatings on the sealing of cork stoppers

Natural cork stoppers, renowned for their sealing efficacy in wine bottles, face challenges in gas-tightness due to cork surface irregularities. This study investigates the impact of lubricant coatings (silicone or paraffin emulsions), on cork stopper gas-tightness. These coatings facilitate cork conformity to glass, minimizing gaps at the interface and significantly improving sealing capacity. A small amount of lubricant leads to a two-order-of-magnitude reduction in gas flow. However, careful control of coating is crucial to ensure reliable sealing. Additionally, water absorption by cork is proposed to contribute to sealing by generating expansion forces and softening the cork, enhancing conformity to glass.This study emphasizes that natural cork stoppers should be viewed as both sealants and membranes. These findings shed light on the importance of surface treatments and water interaction in achieving reliable sealing in cork stoppers, ultimately ensuring the preservation and quality of bottled wine.

Catchment-Scale Hydrologic Effectiveness of Residential Rain Gardens: A Case Study in Columbia, Maryland, USA

To mitigate the adverse impacts of urban stormwater on streams, watershed managers are increasingly using low-impact development and green infrastructure (LID-GI) stormwater control measures, such as rain gardens—vegetated depressional areas that collect and infiltrate runoff from rooftops and driveways. Their catchment-scale performance, however, can vary widely, and few studies have investigated the cumulative performance of residential rain gardens for event runoff control in intermediate-sized (i.e., 1–10 km2) suburban catchments. We modeled three years of continuous rainfall-runoff from a 3.1 km2 catchment in Columbia, MD, USA, using the Storm Water Management Model (SWMM). Various extents of rain garden implementation at residential houses were simulated (i.e., 25%, 50%, 75%, and 100% coverage) to determine the effects on peak flow, runoff volume, and lag time. On average, treating 100% of residential rooftops in the catchment reduced peak flows by 14.3%, reduced runoff volumes by 11.4%, and increased lag times by 3.2% for the 223 rainfall events during the simulation period. Peak flow reductions were greater for smaller storm events (p < 0.01). Our results show that residential rain gardens can significantly improve the runoff response of suburban catchments, and that they represent an effective and relatively low-cost option for urban watershed management and restoration.

Renal dysfunction in adults following cardiopulmonary bypass is linked to declines in S-nitroso hemoglobin: a case series.

Impaired kidney function is frequently observed in patients following cardiopulmonary bypass (CPB). Our group has previously linked blood transfusion to acute declines in S-nitroso haemoglobin (SNO-Hb; the main regulator of tissue oxygen delivery), reductions in intraoperative renal blood flow, and postoperative kidney dysfunction. While not all CPB patients receive blood, kidney injury is still common. We hypothesized that the CPB procedure itself may negatively impact SNO-Hb levels leading to renal dysfunction. After obtaining written informed consent, blood samples were procured immediately before and after CPB, and on postoperative day (POD) 1. SNO-Hb levels, renal function (estimated glomerular filtration rate; eGFR), and plasma erythropoietin (EPO) concentrations were quantified. Additional outcome data were extracted from the patients' medical records. Twenty-seven patients were enroled, three withdrew consent, and one was excluded after developing bacteremia. SNO-Hb levels declined after surgery and were directly correlated with declines in eGFR (R=0.48). Conversely, plasma EPO concentrations were elevated and inversely correlated with SNO-Hb (R=-0.53) and eGFR (R=-0.55). Finally, ICU stay negatively correlated with SNO-Hb concentration (R=-0.32). SNO-Hb levels are reduced following CPB in the absence of allogenic blood transfusion and are predictive of decreased renal function and prolonged ICU stay. Thus, therapies directed at maintaining or increasing SNO-Hb levels may improve outcomes in adult patients undergoing cardiac surgery.

Unveiling Lovastatin’s Anti-Inflammatory Potential in Mouse’s Brain during Acute Trypanosoma cruzi Infection

Neurological commitment is a neglected manifestation of Chagas disease (CD). Meningoencephalitis mainly affects children and immunosuppressed patients, while stroke can occur with or without cardiac compromise. One of the possible causes of stroke development is microvascular commitment. Our group previously described that experimental Trypanossoma cruzi acute infection leads to cerebral microvasculopathy. This condition is characterized by decreased capillary density, increased leukocyte rolling and adhesion, and endothelial dysfunction. CD was discovered 114 years ago, and until today, only two drugs have been available for clinical treatment: benznidazole and nifurtimox. Both present a high cure rate for the acute phase (80%) and small cure rate for the chronic phase (20%). In addition, the high occurrence of side-effects, without proper medical follow-up, can result in treatment abandonment. Therefore, the search for new therapeutic schemes is necessary. Statins are drugs already used in the clinic that have several pleiotropic effects including endothelial function improvement, anti-inflammatory action, as well as trypanocidal effects, making them a potential alternative treatment for brain microvasculopathy in CD. Here, we investigate the effect of lovastatin (LOV) on brain microvasculopathy and inflammatory parameters. Swiss Webster mice were intraperitoneally inoculated with the Y strain of T. cruzi. Treatment with lovastatin (20 mg/kg/day) was initiated 24 h after the infection and continued for 14 consecutive days. We observed that LOV treatment did not affect parasitemia, brain microcirculation alterations, or the reduction in cerebral blood flow caused by T. cruzi infection. Also, LOV did not prevent the increased number of CD3+ cells and eNOS levels in the T. cruzi-infected brain. No alterations were observed on VCAM-1 and MCP-1 expressions, neither caused by infection nor LOV treatment. However, LOV prevented the increase in F4/80+ cells and ICAM-1 levels in the brain caused by acute infection with T. cruzi. These results suggest an anti-inflammatory activity of LOV, but more studies are needed to elucidate the role of LOV in CD acute infection.

Evaluation of water shortage and instream flows of shared rivers in South Korea according to the dam operations in North Korea

Abstract The Korean Peninsula's mountainous terrain poses challenges to effective water resource management. Notably, two significant river basins, North Han River and Imjin River basins, are essentially shared rivers originating in North Korea. After the construction of various dams in North Korea, billions of tons per year of water annually decreased from the upper reaches of these rivers of North Korea to South Korea. This study conducted an impact analysis on two major river basins affected by dam operations in North Korea. Both before and after the Imnam Dam operation, significant reduction (27.7%) in the average monthly inflow was observed, and the total release of the Hwacheon Dam in South Korea decreased by 40.2%. The analysis of instream flow indicated that the operation of dams in North Korea had a substantial impact on fulfilling instream flow requirements for dams located in North Han River and Imjin River basins. To ensure instream flow, this study proposed two plans. The first plan involved the utilization of existing dams in the North Han River basin, while the second plan suggested connecting the dams in North Korea, taking into account the shared rivers.

Desenvolvimento de um modelo de fluxo de águas subterrâneas de elementos finitos para testar estratégias de gestão de drenagem para a expansão da mina a céu aberto de Dareh-Zar, Irã

AbstractA finite-element groundwater flow model was developed for the expanding Dareh-Zar open pit mine in southern Iran, to simulate groundwater inflow into the excavation and mine wall pore pressure dynamics. The model was used to test the effectiveness of implementing different drainage management strategies to reduce groundwater inflow rates and mine wall pore pressures, including abstraction wells and horizontal drains. Model predictions suggest the implementation of abstraction wells will reduce groundwater inflow rates by 75% during the first 12 years of mining and 50% during the subsequent 5 years relative to a ‘no drainage’ management scenario, with further reductions in groundwater inflow achieved through horizontal drain installation. Furthermore, the installation of horizontal drains was found to be necessary to reduce mine-wall pore pressures from destabilizing the mine walls. Groundwater management of the decommissioned pit mine was also evaluated, with simulation results suggesting that backfilling the excavation would restore the groundwater level within the open pit mine region to ~2,442 m above sea level, representing a net restoration of ~204 m relative to the water table prior to mine closure.

Quantifying the scale of erosion along major coastal aquifers of Pakistan using geospatial and machine learning approaches.

Insufficient freshwater recharge and climate change resulted in seawater intrusion in most of the coastal aquifers in Pakistan. Coastal aquifers represent diverse landcover types with varying spectral properties, making it challenging to extract information about their state hence, such investigation requires a combination of geospatial tools. This study aims to monitor erosion along the major coastal aquifers of Pakistan and propose an approach that combines data fusion into the machine and deep learning image segmentation architectures for the erosion and accretion assessment in seascapes. The analysis demonstrated the image segmentation U-Net with EfficientNet backbone achieved the highest F1 score of 0.93, while ResNet101 achieved the lowest F1 score of 0.77. Resultant erosion maps indicated that Sandspit experiencing erosion at 3.14 km2 area. Indus delta is showing erosion, approximately 143 km2 of land over the past 30years. Sonmiani has undergone substantial erosion with 52.2 km2 land. Miani Hor has experienced erosion up to 298 km2, Bhuri creek has eroded over 4.11 km2, east Phitii creek over 3.30 km2, and Waddi creek over 3.082 km2 land. Tummi creek demonstrates erosion, at 7.12 km2 of land, and East Khalri creek near Keti Bandar has undergone a measured loss of 5.2 km2 landlinked with quantified reduction in the vertical sediment flow from 50 (billion cubic meters) to 10 BCM. Our analysis suggests that intense erosions are primarily a result of reduced sediment flow and climate change. Addressing this issue needs to be prioritized coastal management and climate change mitigation framework in Pakistan to safeguard communities. Leveraging emerging solutions, such as loss and damage financing and the integration of nature-based solutions (NbS), should be prioritized for the revival of the coastal aquifers.

Improved sieving coefficient in perfusion cell culture with reduced effective filtration length of hollow fibers.

The hollow fiber filter is the primary cell-retention device used in high-density perfusion cell culture and often used in an alternating tangential flow (ATF) configuration. The limited commercially available diaphragm pumps for ATF prevent utilization of vertical space when scaling beyond 500 L. Stacking hollow fiber filters coupled with viscous cell culture imposes vacuum pressure exceeding facility capabilities. Additionally, the longer filter assembly increases the hold-up volume and exceeds the diaphragm pump's fluid exchange capacity. The conventional tangential flow filtration (TFF) configuration circumvents this issue by exchanging culture from the bioreactor and cell-retention device in a unidirectional recirculation loop; however, the increased filter length when scaled up exacerbates the TFF's inherent issue with product retention from Starling flow. Stacking commercially available 20 cm TFF filters to make up the similar single-module length TFF used for the platform 3 and 50 L perfusion process at 41.5 and 65 cm, respectively, attempts to reduce fouling caused by Starling flow. The permeate of a single-module filter is partitioned into short independent segments through serially stacked filters, each harvested separately. By partitioning the permeate, the sieving coefficient increased for both 3 and 50 L scales. Reduction of Starling flow was confirmed with lower total hydraulic membrane resistance throughout the culture. This work demonstrates a method for increasing sieving coefficient and filter capacity by stacking TFF filters with independent permeate streams.

Symplectic reduction of the sub-Riemannian geodesic flow for metabelian nilpotent groups

We consider nilpotent Lie groups for which the derived subgroup is abelian. We equip them with sub-Riemannian metrics and we study the normal Hamiltonian flow on the cotangent bundle. We show a correspondence between normal trajectories and polynomial Hamiltonians in some Euclidean space. We use the aforementioned correspondence to give a criterion for the integrability of the normal Hamiltonian flow. As an immediate consequence, we show that in Engel-type groups the flow of the normal Hamiltonian is integrable. For Carnot groups that are semidirect products of two abelian groups, we give a set of conditions that normal trajectories must fulfill to be globally length-minimizing. Our results are based on a symplectic reduction procedure.

Comparison of Flow Reduction Efficacy of Nominal and Oversized Flow Diverters Using aNovel Measurement-assisted in Silico Method.

The high efficacy of flow diverters (FD) in the case of wide-neck aneurysms is well demonstrated, yet new challenges have arisen because of reported posttreatment failures and the growing number of new generation of devices. Our aim is to present ameasurement-supported in silico workflow that automates the virtual deployment and subsequent hemodynamic analysis of FDs. In this work, the objective is to analyze the effects of FD deployment variability of two manufacturers on posttreatment flow reduction. The virtual deployment procedure is based on detailed mechanical calibration of the flow diverters, while the flow representation is based on hydrodynamic resistance (HR) measurements. Computational fluid dynamic simulations resulted in 5 untreated and 80virtually treated scenarios, including 2 FD designs in nominal and oversized deployment states. The simulated aneurysmal velocity reduction (AMVR) is correlated with the HR values and deployment scenarios. The linear HR coefficient and AMVR revealed apower-law relationship considering all 80 deployments. In nominal deployment scenarios, asignificantly larger average AMVR was obtained (60.3%) for the 64-wire FDs than for 48-wire FDs (51.9%). In oversized deployments, the average AMVR was almost the same for 64-wire and 48-wire device types, 27.5% and 25.7%, respectively. The applicability of our numerical workflow was demonstrated, also in large-scale hemodynamic investigations. The study revealed arobust power-law relationship between aHR coefficient and AMVR. Furthermore, the 64wire configurations in nominal sizing produced asignificantly higher posttreatment flow reduction, replicating the results of other in vitro studies.